Smartbeads

Ultrapure animal-free chitosan-based Smartbeads to boost the clinical efficacy and residency of viscosupplements within joints

About Smartbeads

Smartbeads are a breakthrough technology that is capable of increasing the efficacy and residency of existing hyaluronic acid viscosupplementation products in the treatment and pain relief of Osteoarthritis.

The Smartbeads are three-dimensionally compressible and deformable gel microbeads of ~200-µm in diameter, which are made of animal-free ultrapure chitosan. The microbeads act by enhancing the shock absorption capability of a viscosupplement in a long-lasting way.

Qualities

Chondroprotection and a favorable rheological profile are both key elements in terms of slowing down the progression of the disease in patients who suffer from Osteoarthritis. This was the basis for the creation of the Smartbeads.

We have succeeded in proving that the Smartbeads are capable of boosting the efficacy of the current leading viscosupplements (see Arthrovisc). Applications already use the Smartbeads technology to boost the efficiency of their product.

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Osteoarthritis progression

The combination of Smartbeads with a hydrogel ensured the slowing down of Osteoarthritis (OA) progression in an OA rabbit model. This was generally acknowledged to be very challenging for evaluating the efficacy of viscosupplements. After seven weeks of disease progression, the OA level was lower in the rabbit groups that were treated with Smartbeads than the control groups evaluated by X-ray radiography using the Kellgren & Lawrence OA scale.

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Osteoarthritis progression

The combination of Smartbeads with a hydrogel allowed for the slowing down of OA progression in an OA rabbit model. This is generally acknowledged as very challenging for evaluating the efficacy of viscosupplements. After seven weeks of disease progression, the OA level was lower in the rabbit groups that were treated with Smartbeads than the control groups as evaluated by histological assessment of cartilage quality.

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